Rinse the cleaned chitterlings thoroughly in cold water, inspecting each piece.
Bring a large pot of water to a simmer and add onion, garlic powder, onion powder, sea salt, pepper parts, and pepper sauce.
Add the chitterlings to the pot and boil for 20 minutes.
Reduce heat to a steady simmer.
Add Louisiana hot sauce and optional smoked turkey pieces.
Simmer 3–5 hours, stirring occasionally, until tender.
Taste and adjust seasoning with additional salt, pepper sauce, or hot sauce.
Serve hot alongside your Thanksgiving meal.